How CBD works for patients with drug-resistant epilepsy

Drug-resistant epilepsy affects approximately 30-40% of patients who do not respond to traditional antiepileptic drugs (AEDs). In recent years, cannabidiol (CBD), one of the main chemical compounds found in cannabis, has gained importance as a potential therapeutic alternative. Numerous clinical studies and individual cases indicate its effectiveness in reducing epileptic seizures, especially in drug-resistant cases.

CBD mechanism of action

CBD affects the nervous system by modulating neurotransmitters (chemical molecules that nerve cells use to communicate with each other). In the case of epilepsy, excessive electrical discharges occur in the brain’s neurons, which leads to seizures. Cannabinoids, including CBD, can weaken or completely inhibit the excitation of some neurotransmitters, which effectively counteracts them [1]. The human body itself produces cannabinoids, such as anandamide, which have protective functions for the nervous system. In cases of deficiency of these compounds, exocannabinoids, such as CBD, can support their action [1].

Do clinical studies confirm CBD’s effectiveness?

Clinical studies support CBD’s efficacy in treating drug-resistant epilepsy. Three “double-blind” studies (neither participants nor researchers knew who received which sample) found that children and adolescents taking CBD experienced significant improvement in epilepsy symptoms compared to the placebo group [1]. The World Health Organization (WHO) and the FDA have approved Epidiolex, an oral CBD solution, for the treatment of seizures associated with Dravet syndrome and Lennox-Gastaut syndrome, a significant step in recognizing CBD as an effective treatment [2].

Mrs. Gudaniec’s Story

One of the most famous cases proving the effectiveness of CBD is the story of Mrs. Dorota Gudaniec, whose son suffers from a severe form of drug-resistant epilepsy. Traditional treatment methods did not bring results, and the seizures were frequent and intense. After starting therapy with CBD extract, the number of seizures in her son decreased significantly, which improved the quality of life of the entire family. This story became an inspiration for many other parents and patients looking for alternative methods of treatment [3], and hemp oil became widely known.

Recommendations and Dosage of CBD Oil for Epilepsy Treatment

Experts recommend starting CBD therapy with low doses, such as 2-5 mg per kilogram of body weight per day, and gradually increasing them while monitoring for possible side effects [4]. The most common adverse events are drowsiness, diarrhea, decreased appetite and body weight. High doses may be associated with the risk of hepatotoxicity, so monitoring liver function is necessary [4].

CBD Hemp Oil for Epilepsy and Drug-Resistant Epilepsy – Summary

CBD has shown promising results in treating drug-resistant epilepsy, especially in cases where traditional medications fail. Groundbreaking clinical trials and patient testimonials, such as Mrs. Gudaniec’s son, support its efficacy and safety. However, further research is needed to fully understand the mechanisms of CBD’s action and optimize its dosage.

Sources:

1. https://biokonopia.pl/blog/post/29-cbd-na-epilepsje-i-padaczke-lekooporna
2. https://www.doz.pl/czytelnia/a17940-CBD_w_leczeniu_epilepsji__przelomowe_badania
3. https://biohemp.pl/pl/blog/pacjent-zero-cbd-historia-charlotte-figi-chorej-na-padaczke/
4. https://www.termedia.pl/neurologia/Zalecenia-dotyczace-stosowania-kannabinoidow-w-terapii-padaczki-lekoopornej,46489.html
5. https://www.cannabaorganics.store/skutecznosc-kannabidiolu-cbd-w-leczeniu-padaczki-lekoopornej